منابع مشابه
Calorie restriction in humans: An update.
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate nutrition, has been shown to extend healthspan and lifespan in rodent and primate models. Accumulating data from observational and randomized clinical trials indicate that CR in humans results in some of the same metabolic and molecular adaptations that have been shown to improve health and retard th...
متن کاملWill calorie restriction work in humans?
Calorie Restriction (CR) without malnutrition slows aging and increases average and maximal lifespan in simple model organisms and rodents. In rhesus monkeys long-term CR reduces the incidence of type 2 diabetes, cardiovascular disease and cancer, and protects against age-associated sarcopenia and neurodegeneration. However, so far CR significantly increased average lifespan only in the Wiscons...
متن کاملUpdate on human calorie restriction research.
The United States population is aging rapidly, and understanding the potential impact and feasibility of lifestyle interventions on the aging process is of central importance for addressing future population health and health care costs. This symposium addressed the question of whether caloric restriction may be a feasible strategy to improve human health by reductions in rates of primary and s...
متن کاملCalorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
BACKGROUND Caloric restriction without malnutrition extends life span in a range of organisms including insects and mammals and lowers free radical production by the mitochondria. However, the mechanism responsible for this adaptation are poorly understood. METHODS AND FINDINGS The current study was undertaken to examine muscle mitochondrial bioenergetics in response to caloric restriction al...
متن کاملCalorie restriction as an intervention in ageing
Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory process and affects life- and healthspan. Calorie restriction (CR) is a non-genetic intervention that prevents age-associated diseases and extends longevity in most of the animal models studied so far. CR produces a pleiotropic effect and improves multiple metabolic pathways, generating benefits to th...
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ژورنال
عنوان ژورنال: Ageing Research Reviews
سال: 2017
ISSN: 1568-1637
DOI: 10.1016/j.arr.2016.08.005